Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

Jun Chen; Xixi Zhang; Reid Millican; Jennifer Sherwood; Sean Martin; Hanjoong Jo; Young-Sup Yoon; Brigitta C Brott; Ho-Wook Jun

doi:10.1016/j.addr.2021.01.005

Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

Adv Drug Deliv Rev. 2021 Mar:170:142-199. doi: 10.1016/j.addr.2021.01.005. Epub 2021 Jan 9.

Authors

Jun Chen¹, Xixi Zhang¹, Reid Millican², Jennifer Sherwood², Sean Martin¹, Hanjoong Jo³, Young-Sup Yoon⁴, Brigitta C Brott⁵, Ho-Wook Jun⁶

Affiliations

¹ Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United States.
² Endomimetics, LLC., Birmingham, AL, United States.
³ Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States; Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA, United States.
⁴ Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea.
⁵ Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
⁶ Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United States. Electronic address: hwjun@uab.edu.

Abstract

Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in arteries, leading to narrowing and thrombosis. It affects the heart, brain, and peripheral vessels and is the leading cause of mortality in the United States. Researchers have strived to design nanomaterials of various functions, ranging from non-invasive imaging contrast agents, targeted therapeutic delivery systems to multifunctional nanoagents able to target, diagnose, and treat atherosclerosis. Therefore, this review aims to summarize recent progress (2017-now) in the development of nanomaterials and their applications to improve atherosclerosis diagnosis and therapy during the preclinical and clinical stages of the disease.

Keywords: Atherosclerosis; Clinical use; Imaging contrast agents; Nanomaterials; Theranostic agents; Therapeutic delivery system.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Atherosclerosis* / diagnosis
Atherosclerosis* / drug therapy
Humans
Nanostructures* / chemistry
Nanostructures* / therapeutic use

Abstract

Publication types

MeSH terms

Grants and funding