My Bibliography

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Jason J, Archibald LK, Nwanyanwu OC, Kazembe PN, Chatt JA, Norton E, Dobbie H, Jarvis WR. Clinical and immune impact of Mycobacterium bovis BCG vaccination scarring. Infect Immun. 2002 Nov;70(11):6188-95. doi: 10.1128/IAI.70.11.6188-6195.2002. PubMed PMID: 12379697; PubMed Central PMCID: PMC130324.

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Norton EB, Archibald LK, Nwanyanwu OC, Kazembe PN, Dobbie H, Reller LB, Jarvis WR, Jason J. Clinical predictors of bloodstream infections and mortality in hospitalized Malawian children. Pediatr Infect Dis J. 2004 Feb;23(2):145-51; discussion 151-5. doi: 10.1097/01.inf.0000109258.82988.40. PubMed PMID: 14872181.

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Norton EB, Clements JD, Voss TG, Cárdenas-Freytag L. Prophylactic administration of bacterially derived immunomodulators improves the outcome of influenza virus infection in a murine model. J Virol. 2010 Mar;84(6):2983-95. doi: 10.1128/JVI.01805-09. Epub 2010 Jan 6. PubMed PMID: 20053748; PubMed Central PMCID: PMC2826051.

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Norton EB, Lawson LB, Freytag LC, Clements JD. Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant. Clin Vaccine Immunol. 2011 Apr;18(4):546-51. doi: 10.1128/CVI.00538-10. Epub 2011 Feb 2. PubMed PMID: 21288994; PubMed Central PMCID: PMC3122563.

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Cross RW, Betancourt AM, Schur MJ, Norton EB, Roy D, Hartley T, Voss GV. Impact of Primary Influenza Infection on the Immune Response to Secondary Bacterial Infection in Aged Mice. [Print]. Symposium on viral respiratory disease surveillance. Influenza and Other Respiratory Viruses.; 2011 May. (Suppl. 1), 195–201.

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Cross RW, Betancourt AM, Schur MJ, Norton EB, Roy D, Hartley T, Voss TG. Impact of primary influenza infection on the immune response to secondary bacterial infection in aged mice. Influenza Other Respir Viruses. 2011 May;5(Suppl 1):198-201. PubMed PMID: 29415086; PubMed Central PMCID: PMC4172348.

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Lawson LB, Norton EB, Clements JD. Defending the mucosa: adjuvant and carrier formulations for mucosal immunity. Curr Opin Immunol. 2011 Jun;23(3):414-20. doi: 10.1016/j.coi.2011.03.009. Epub 2011 Apr 19. Review. PubMed PMID: 21511452.

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Norton EB, Lawson LB, Mahdi Z, Freytag LC, Clements JD. The A subunit of Escherichia coli heat-labile enterotoxin functions as a mucosal adjuvant and promotes IgG2a, IgA, and Th17 responses to vaccine antigens. Infect Immun. 2012 Jul;80(7):2426-35. doi: 10.1128/IAI.00181-12. Epub 2012 Apr 23. PubMed PMID: 22526674; PubMed Central PMCID: PMC3416479.

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Tomchuck SL, Norton EB, Garry RF, Bunnell BA, Morris CA, Freytag LC, Clements JD. Mesenchymal stem cells as a novel vaccine platform. Front Cell Infect Microbiol. 2012;2:140. doi: 10.3389/fcimb.2012.00140. eCollection 2012. PubMed PMID: 23162801; PubMed Central PMCID: PMC3499769.

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White JA, Blum JS, Hosken NA, Marshak JO, Duncan L, Zhu C, Norton EB, Clements JD, Koelle DM, Chen D, Weldon WC, Oberste MS, Lal M. Serum and mucosal antibody responses to inactivated polio vaccine after sublingual immunization using a thermoresponsive gel delivery system. Hum Vaccin Immunother. 2014;10(12):3611-21. doi: 10.4161/hv.32253. PubMed PMID: 25483682; PubMed Central PMCID: PMC4514067.

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Read LT, Hahn RW, Thompson CC, Bauer DL, Norton EB, Clements JD. Simultaneous exposure to Escherichia coli heat-labile and heat-stable enterotoxins increases fluid secretion and alters cyclic nucleotide and cytokine production by intestinal epithelial cells. Infect Immun. 2014 Dec;82(12):5308-16. doi: 10.1128/IAI.02496-14. Epub 2014 Oct 6. PubMed PMID: 25287923; PubMed Central PMCID: PMC4249298.

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Norton EB, Bauer DL, Weldon WC, Oberste MS, Lawson LB, Clements JD. The novel adjuvant dmLT promotes dose sparing, mucosal immunity and longevity of antibody responses to the inactivated polio vaccine in a murine model. Vaccine. 2015 Apr 15;33(16):1909-15. doi: 10.1016/j.vaccine.2015.02.069. Epub 2015 Mar 9. PubMed PMID: 25765967.

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Norton EB, Branco LM, Clements JD. Evaluating the A-Subunit of the Heat-Labile Toxin (LT) As an Immunogen and a Protective Antigen Against Enterotoxigenic Escherichia coli (ETEC). PLoS One. 2015;10(8):e0136302. doi: 10.1371/journal.pone.0136302. eCollection 2015. PubMed PMID: 26305793; PubMed Central PMCID: PMC4549283.

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Clements JD, Norton EB. The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT. mSphere. 2018 Jul 25;3(4). doi: 10.1128/mSphere.00215-18. Review. PubMed PMID: 30045966; PubMed Central PMCID: PMC6060342.

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Norton EB. Altered responses to pneumococcal vaccination in an elderly diabetic Japanese vaccine trial: The risk of concurrent vaccination strategies. J Diabetes Complications. 2019 Mar;33(3):189-190. doi: 10.1016/j.jdiacomp.2018.12.007. Epub 2018 Dec 21. PubMed PMID: 30651178.

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Valli E, Harriett AJ, Nowakowska MK, Baudier RL, Provosty WB, McSween Z, Lawson LB, Nakanishi Y, Norton EB. LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice. Sci Rep. 2019 Oct 22;9(1):15128. doi: 10.1038/s41598-019-51356-w. PubMed PMID: 31641151; PubMed Central PMCID: PMC6805908.

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Maciel M Jr, Bauer D, Baudier RL, Bitoun J, Clements JD, Poole ST, Smith MA, Kaminski RW, Savarino SJ, Norton EB. Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic Escherichia coli. Infect Immun. 2019 Nov;87(11). doi: 10.1128/IAI.00460-19. Print 2019 Nov. PubMed PMID: 31427449; PubMed Central PMCID: PMC6803349.

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Combs JA, Norton EB, Saifudeen ZR, Bentrup KHZ, Katakam PV, Morris CA, Myers L, Kaur A, Sullivan DE, Zwezdaryk KJ. Human Cytomegalovirus Alters Host Cell Mitochondrial Function during Acute Infection. J Virol. 2020 Jan 6;94(2). doi: 10.1128/JVI.01183-19. Print 2020 Jan 6. PubMed PMID: 31694945; PubMed Central PMCID: PMC6955246.

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Valli E, Baudier RL, Harriett AJ, Norton EB. LTA1 and dmLT enterotoxin-based proteins activate antigen-presenting cells independent of PKA and despite distinct cell entry mechanisms. PLoS One. 2020;15(1):e0227047. doi: 10.1371/journal.pone.0227047. eCollection 2020. PubMed PMID: 31929548; PubMed Central PMCID: PMC6957164.

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Liu S, Liu F, Zhang B, Yan P, Rowan BG, Abdel-Mageed AB, Steele C, Jazwinski SM, Moroz K, Norton EB, Wang A, Myers L, Sartor O, Zhang Q. CD4(+) T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion. Prostate. 2020 Jul;80(10):764-776. doi: 10.1002/pros.23990. Epub 2020 May 1. PubMed PMID: 32356608; PubMed Central PMCID: PMC7310589.

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Baudier RL, Zwezdaryk KJ, Czarny-Ratajczak M, Kodroff LH, Sullivan DE, Norton EB. Unique Transcriptome Changes in Peripheral B Cells Revealed by Comparing Age Groups From Naive or Vaccinated Mice, Including snoRNA and Cdkn2a. J Gerontol A Biol Sci Med Sci. 2020 Nov 13;75(12):2326-2332. doi: 10.1093/gerona/glaa165. PubMed PMID: 32609344; PubMed Central PMCID: PMC7759738.

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Motyka NI, Stewart SR, Hollifield IE, Kyllo TR, Mansfield JA, Norton EB, Clements JD, Bitoun JP. Elevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli Heat-Stable Toxin Induces Epithelial IL-33 Release and Alters Intestinal Immunity. Infect Immun. 2021 Mar 17;89(4). doi: 10.1128/IAI.00707-20. Print 2021 Mar 17. PubMed PMID: 33431701; PubMed Central PMCID: PMC8090939.

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Huang Z, Ning B, Yang HS, Youngquist BM, Niu A, Lyon CJ, Beddingfield BJ, Fears AC, Monk CH, Murrell AE, Bilton SJ, Linhuber JP, Norton EB, Dietrich ML, Yee J, Lai W, Scott JW, Yin XM, Rappaport J, Robinson JE, Saba NS, Roy CJ, Zwezdaryk KJ, Zhao Z, Hu TY. Sensitive tracking of circulating viral RNA through all stages of SARS-CoV-2 infection. J Clin Invest. 2021 Apr 1;131(7). doi: 10.1172/JCI146031. PubMed PMID: 33561010; PubMed Central PMCID: PMC8011898.

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Stone AE, Scheuermann SE, Haile CN, Cuny GD, Velasquez ML, Linhuber JP, Duddupudi AL, Vigliaturo JR, Pravetoni M, Kosten TA, Kosten TR, Norton EB. Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge. NPJ Vaccines. 2021 May 13;6(1):69. doi: 10.1038/s41541-021-00329-0. PubMed PMID: 33986280; PubMed Central PMCID: PMC8119695.

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Schieffelin JS, Norton EB, Kolls JK. What should define a SARS-CoV-2 "breakthrough" infection?. J Clin Invest. 2021 Jun 15;131(12). doi: 10.1172/JCI151186. PubMed PMID: 33974565; PubMed Central PMCID: PMC8203469.

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Bhattacharjee A, Burr AHP, Overacre-Delgoffe AE, Tometich JT, Yang D, Huckestein BR, Linehan JL, Spencer SP, Hall JA, Harrison OJ, Morais da Fonseca D, Norton EB, Belkaid Y, Hand TW. Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy. Immunity. 2021 Aug 10;54(8):1745-1757.e7. doi: 10.1016/j.immuni.2021.07.005. Epub 2021 Aug 3. PubMed PMID: 34348118; PubMed Central PMCID: PMC8415388.

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Iwanaga N, Chen K, Yang H, Lu S, Hoffmann JP, Wanek A, McCombs JE, Song K, Rangel-Moreno J, Norton EB, Kolls JK. Vaccine-driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling. Sci Immunol. 2021 Sep 10;6(63):eabf1198. doi: 10.1126/sciimmunol.abf1198. Epub 2021 Sep 10. PubMed PMID: 34516780; PubMed Central PMCID: PMC8796208.

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Combs JA, Monk CH, Harrison MAA, Norton EB, Morris CA, Sullivan DE, Zwezdaryk KJ. Inhibiting cytomegalovirus replication through targeting the host electron transport chain. Antiviral Res. 2021 Oct;194:105159. doi: 10.1016/j.antiviral.2021.105159. Epub 2021 Aug 11. PubMed PMID: 34390771; PubMed Central PMCID: PMC8446325.

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Dietrich ML, Norton EB, Elliott D, Smira AR, Raviv O, Sasson DJ, Monk CH, Michael ML, Rogers N, Rouelle JA, Bond NG, Aime-Marcelin K, Prystowsky A, Kemnitz R, Sarma A, Himmelfarb ST, Sharma N, Stone AE, Craver R, Lindrose AR, Smitley LA, Uddo RB, Myers L, Drury SS, Schieffelin JS, Robinson JE, Zwezdaryk KJ. SARS-CoV-2 seroprevalence rates of children seeking medical care in Louisiana during the state stay at home order. J Clin Virol Plus. 2021 Dec;1(4):100047. doi: 10.1016/j.jcvp.2021.100047. Epub 2021 Nov 14. PubMed PMID: 35262027; PubMed Central PMCID: PMC8590598.

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Crothers JW, Ross Colgate E, Cowan KJ, Dickson DM, Walsh M, Carmolli M, Wright PF, Norton EB, Kirkpatrick BD. Intradermal fractional-dose inactivated polio vaccine (fIPV) adjuvanted with double mutant Enterotoxigenic Escherichia coli heat labile toxin (dmLT) is well-tolerated and augments a systemic immune response to all three poliovirus serotypes in a randomized placebo-controlled trial. Vaccine. 2022 Apr 26;40(19):2705-2713. doi: 10.1016/j.vaccine.2022.03.056. Epub 2022 Mar 30. PubMed PMID: 35367069; PubMed Central PMCID: PMC9024222.

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Bucşan AN, Veatch A, Singh DK, Akter S, Golden NA, Kirkpatrick M, Threeton B, Moodley C, Ahmed M, Doyle LA, Russell-Lodrigue K, Norton EB, Didier PJ, Roy CJ, Abramovitch RB, Mehra S, Khader SA, Kaushal D. Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts Mycobacterium tuberculosis Pathogenicity. Am J Respir Crit Care Med. 2022 Jul 1;206(1):94-104. doi: 10.1164/rccm.202112-2747OC. PubMed PMID: 35412961; PubMed Central PMCID: PMC9718519.

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Seifert SN, Bai S, Fawcett S, Norton EB, Zwezdaryk KJ, Robinson J, Gunn B, Letko M. An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines. PLoS Pathog. 2022 Sep;18(9):e1010828. doi: 10.1371/journal.ppat.1010828. eCollection 2022 Sep. PubMed PMID: 36136995; PubMed Central PMCID: PMC9498966.

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Haile CN, Baker MD, Sanchez SA, Lopez Arteaga CA, Duddupudi AL, Cuny GD, Norton EB, Kosten TR, Kosten TA. An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats. Pharmaceutics. 2022 Oct 26;14(11). doi: 10.3390/pharmaceutics14112290. PubMed PMID: 36365109; PubMed Central PMCID: PMC9694531.

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Kosten TR, Haile CN, Domingo CB, Norton EB. Anti-Cocaine IgA Rather Than IgG Mediates Vaccine Protection from Cocaine Use. Pharmaceutics. 2022 Nov 3;14(11). doi: 10.3390/pharmaceutics14112368. PubMed PMID: 36365186; PubMed Central PMCID: PMC9697488.

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Ning B, Chandra S, Rosen J, Multala E, Argrave M, Pierson L, Trinh I, Simone B, Escarra MD, Drury S, Zwezdaryk KJ, Norton E, Lyon CJ, Hu T. Evaluation of SARS-CoV-2-Specific T-Cell Activation with a Rapid On-Chip IGRA. ACS Nano. 2023 Jan 3;17(2):1206-16. doi: 10.1021/acsnano.2c09018. [Epub ahead of print] PubMed PMID: 36595218; PubMed Central PMCID: PMC9878992.

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Estrada MR, Bzami A, Norton EB, White JA. Identifying a stable bulk dmLT adjuvant formulation at a clinically relevant concentration. Vaccine. 2023 Feb 10;41(7):1362-1367. doi: 10.1016/j.vaccine.2023.01.005. Epub 2023 Jan 17. PubMed PMID: 36658044; PubMed Central PMCID: PMC9932622.

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Stone AE, Rambaran S, Trinh IV, Estrada M, Jarand CW, Williams BS, Murrell AE, Huerter CM, Bai W, Palani S, Nakanishi Y, Laird RM, Poly FM, Reed WF, White JA, Norton EB. Route and antigen shape immunity to dmLT-adjuvanted vaccines to a greater extent than biochemical stress or formulation excipients. Vaccine. 2023 Feb 24;41(9):1589-1601. doi: 10.1016/j.vaccine.2023.01.033. Epub 2023 Jan 31. PubMed PMID: 36732163; PubMed Central PMCID: PMC10308557.

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Landry SJ, Mettu RR, Kolls JK, Aberle JH, Norton E, Zwezdaryk K, Robinson J. Structural Framework for Analysis of CD4+ T-Cell Epitope Dominance in Viral Fusion Proteins. Biochemistry. 2023 Sep 5;62(17):2517-2529. doi: 10.1021/acs.biochem.3c00335. Epub 2023 Aug 9. Review. PubMed PMID: 37554055; PubMed Central PMCID: PMC10483696.

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Crothers JW, Norton EB. Recent advances in enterotoxin vaccine adjuvants. Curr Opin Immunol. 2023 Dec;85:102398. doi: 10.1016/j.coi.2023.102398. Epub 2023 Nov 16. Review. PubMed PMID: 37976963.

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Zhang B, Chen S, Yin X, McBride CD, Gertie JA, Yurieva M, Bielecka AA, Hoffmann B, Travis Hinson J, Grassmann J, Xu L, Siniscalco ER, Soldatenko A, Hoyt L, Joseph J, Norton EB, Uthaman G, Palm NW, Liu E, Eisenbarth SC, Williams A. Metabolic fitness of IgA(+) plasma cells in the gut requires DOCK8. Mucosal Immunol. 2023 Dec 28;. doi: 10.1016/j.mucimm.2023.12.001. [Epub ahead of print] PubMed PMID: 38159726.

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Lauritsen CJ, Trinh IV, Desai SP, Clancey E, Murrell AE, Rambaran S, Chandra S, Elliott DH, Smira AR, Mo Z, Stone AE, Agbodji A, Dugas CM, Satou R, Pridjian G, Longo S, Ley SH, Robinson JE, Norton EB, Piedimonte G, Gunn BM. Passive antibody transfer from pregnant women to their fetus are maximized after SARS-CoV-2 vaccination irrespective of prior infection. J Allergy Clin Immunol Glob. 2024 Feb;3(1):100189. doi: 10.1016/j.jacig.2023.100189. eCollection 2024 Feb. PubMed PMID: 38268538; PubMed Central PMCID: PMC10805668.

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Shafieichaharberoud F, Lang S, Whalen C, Rivera Quiles C, Purcell L, Talbot C, Wang P, Norton EB, Mazei-Robison M, Sulima A, Jacobson AE, Rice KC, Matyas GR, Huang X. Enhancing Protective Antibodies against Opioids through Antigen Display on Virus-like Particles. Bioconjug Chem. 2024 Feb 21;35(2):164-173. doi: 10.1021/acs.bioconjchem.3c00415. Epub 2023 Dec 19. PubMed PMID: 38113481.

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Harrison MAA, Morris SL, Rudman GA, Rittenhouse DJ, Monk CH, Sakamuri SSVP, Mehedi Hasan M, Shamima Khatun M, Wang H, Garfinkel LP, Norton EB, Kim S, Kolls JK, Michal Jazwinski S, Mostany R, Katakam PVG, Engler-Chiurazzi EB, Zwezdaryk KJ. Intermittent cytomegalovirus infection alters neurobiological metabolism and induces cognitive deficits in mice. Brain Behav Immun. 2024 Mar;117:36-50. doi: 10.1016/j.bbi.2023.12.033. Epub 2024 Jan 3. PubMed PMID: 38182037.

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Patel DR, Minns AM, Sim DG, Field CJ, Kerr AE, Heinly TA, Luley EH, Rossi RM, Bator CM, Moustafa IM, Norton EB, Hafenstein SL, Lindner SE, Sutton TC. Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model. Microbiol Spectr. 2024 Mar 5;12(3):e0499822. doi: 10.1128/spectrum.04998-22. Epub 2024 Feb 9. PubMed PMID: 38334387; PubMed Central PMCID: PMC10923206.

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Trinh IV, Desai SP, Ley SH, Mo Z, Satou R, Pridjian GC, Longo SA, Shaffer JG, Robinson JE, Norton EB, Piedimonte G. Prenatal Infection by Respiratory Viruses Is Associated with Immunoinflammatory Responses in the Fetus. Am J Respir Crit Care Med. 2024 Mar 15;209(6):693-702. doi: 10.1164/rccm.202308-1461OC. PubMed PMID: 38051928; PubMed Central PMCID: PMC10945055.

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Hoffmann JP, Srivastava A, Yang H, Iwanaga N, Remcho TP, Hewes JL, Sharoff R, Song K, Norton EB, Kolls JK, McCombs JE. Vaccine-elicited IL-1R signaling results in Th17 TRM-mediated immunity. Commun Biol. 2024 Apr 9;7(1):433. doi: 10.1038/s42003-024-06138-0. PubMed PMID: 38594380; PubMed Central PMCID: PMC11003962.

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Tong S, Scott JC, Eyoh E, Werthmann DW, Stone AE, Murrell AE, Sabino-Santos G, Trinh IV, Chandra S, Elliott DH, Smira AR, Velazquez JV, Schieffelin J, Ning B, Hu T, Kolls JK, Landry SJ, Zwezdaryk KJ, Robinson JE, Gunn BM, Rabito FA, Norton EB. Altered COVID-19 immunity in children with asthma by atopic status. J Allergy Clin Immunol Glob. 2024 May;3(2):100236. doi: 10.1016/j.jacig.2024.100236. eCollection 2024 May. PubMed PMID: 38590754; PubMed Central PMCID: PMC11000189.